Ogan K. Kumova

PhD  ·  Immunologist  ·  Science Policy Professional

I'm a vaccine scientist and science policy professional working at the intersection of immunology and public health decision-making. I currently serve as a Program Officer at the National Academies of Sciences, Engineering, and Medicine, where I lead expert consensus studies on vaccine safety for federal agencies including the CDC, FDA, VA, and DoD.

15
Peer-Reviewed Publications
2
NASEM Reports
20+
Years in Science
20+
Years in Education
4
Federal Agency Partners
6
Research Focus Areas
Ogan K. Kumova
Background
About Me

I've been a scientist at heart since I was six years old — when I got my first microscope and a subscription to Discovery Kids magazine that I read cover to cover every month. I grew up in Turkey asking questions about everything, and that curiosity never really switched off.

My family moved to the United States at the end of middle school, and I finished high school in New Jersey, where I kept finding my way into every science class available. I also started volunteering at the Franklin Institute in Philadelphia during those years, and discovered something important about myself: I loved explaining science just as much as I loved learning it.

That combination took me to the University of the Sciences in Philadelphia, where I earned dual Bachelor of Science degrees in Biochemistry and Bioinformatics. During my undergraduate years I had my first real taste of research, working in the laboratory of Dr. Michael Bruist studying protein-DNA interaction kinetics — and I was immediately hooked. Throughout college I also kept working at the Franklin Institute, bringing science to the public while studying it in class, and served as a teaching assistant. After graduating, I taught at Philadelphia University, helped design curricula, and continued developing science education programs at the Franklin Institute. Those years gave me a real appreciation for science communication and the challenge of making complex ideas click for anyone.

Eventually the researcher in me took over. After my years in science education, I wanted to get back into the lab, so I joined Drexel University College of Medicine as a laboratory technician. Working in the laboratory of Dr. Shira Ninio, I studied how Legionella pneumophila forms biofilms and replicates inside host cells — and while doing that, I pursued my Master of Science in Infectious Diseases at the same time. Getting back to the bench reminded me exactly why I loved research in the first place.

From there I transitioned to the laboratory of Dr. Alison Carey, initially joining as a lab manager before deciding to pursue my Ph.D. in Microbiology and Immunology. My dissertation focused on neonatal immunology — why newborns struggle to mount effective immune responses to respiratory infections and what might be done about it. I studied defects in neonatal CD8+ T cell responses, investigated whether probiotic interventions could improve early viral control during influenza infection, and looked at modifiable risk factors that influence how the neonatal immune system develops. Alongside that work I also collaborated with the Wistar Cancer Institute on DNA-based HIV vaccine development and was part of the 2016 NIH Clinical and Translational Research Cohort. Outside the lab, I served as President of the Graduate Student Association for two years — a role I genuinely enjoyed, both for the community it built and for the chance to advocate for my fellow students.

After completing my Ph.D., I joined the FDA's Office of Vaccine Research and Review as an ORISE Postdoctoral Fellow under Dr. Margaret Bash, where I worked on developing vaccines against Neisseria gonorrhoeae — an increasingly urgent public health problem as antibiotic resistance grows. As a postdoc, I was involved in vaccine candidate development and characterization, ran immunology assays to look at mucosal and systemic immune responses, and contributed to murine immunization studies. I was also part of a broader NIH-U19 multi-site consortium, which gave me great exposure to collaborative science and the FDA's regulatory environment.

From there I joined the National Academies of Sciences, Engineering, and Medicine as a Program Officer focused on vaccine safety, leading expert consensus studies for federal agencies including the CDC, FDA, VA, and DoD. I've contributed to two published National Academies reports and in October 2025 briefed Congressional staff from the Senate HELP Committee and both chambers' Appropriations Committees on COVID-19 vaccine safety.

The curiosity that started with a childhood microscope is still very much the engine. I just have bigger questions now.

Science
Research
Drexel University College of Medicine  ·  PhD

Neonatal Immunology & Respiratory Infection

Investigated why the neonatal immune system is poorly equipped to respond to respiratory infections like influenza. Studied defects in neonatal CD8+ T cell responses, modifiable risk factors, and the potential of probiotic interventions — including Lactobacillus rhamnosus — to restore early viral control in neonates.

FDA Office of Vaccine Research  ·  Postdoctoral Fellow

Gonorrhea Vaccine Development

Developed and characterized liposome- and outer membrane vesicle-based vaccine candidates against Neisseria gonorrhoeae. Designed immunology assays to assess mucosal and systemic immune responses, evaluated routes of immunization in murine models, and contributed to NIH-U19 multi-site consortium grants within the FDA's regulatory science framework.

Drexel University  ·  MS / Lab Technician

Legionella Pathogenesis

Studied the pathogenesis of Legionella pneumophila in the laboratory of Dr. Shira Ninio, focusing on biofilm formation, OmpA-like protein characterization, and intracellular replication mechanisms.

Wistar Cancer Institute  ·  Collaboration

HIV Vaccine Development

Collaborated with the Wistar Cancer Institute on DNA-based HIV vaccine development, contributing to the evaluation of vaccine immunogenicity and adjuvant strategies as part of cross-institutional research efforts during doctoral training.

University of the Sciences  ·  Undergraduate Research

Protein-DNA Interaction Kinetics

Conducted undergraduate research in the laboratory of Dr. Michael Bruist, studying the kinetics of protein-DNA interactions — an early formative experience that set the direction for a career in laboratory science.

NASEM  ·  Policy Research

Vaccine Safety Evidence Synthesis

At the National Academies, leads comprehensive evidence reviews on vaccine safety commissioned by federal agencies. Oversees expert committee processes, evidence synthesis, and the production of consensus reports that directly inform national public health policy.

National Academies
Policy Work

As a Program Officer at the National Academies of Sciences, Engineering, and Medicine, I work within the Biomedical and Health Sciences Program Area (BHS) of the Center for Health, People, and Places (CHPP), where I bring expertise in immunology and vaccine science to support expert consensus studies on vaccine safety, safety monitoring systems, and military and veteran health commissioned by federal agencies including the CDC, VA, DoD, and FDA. This work bridges the gap between scientific evidence and public health decision-making at the highest levels of government.

2024

Evidence Review of the Adverse Effects of COVID-19 Vaccination and Intramuscular Vaccine Administration

A comprehensive evidence review examining adverse effects associated with COVID-19 vaccines and intramuscular vaccine administration, produced for federal health agencies to inform vaccine safety monitoring and policy.

View Full Report →
Interactive: COVID-19 Vaccine Adverse Effects → Interactive: Shoulder Injuries →
2025

Vaccine Risk Monitoring and Evaluation at the Centers for Disease Control and Prevention

An in-depth evaluation of the CDC's vaccine safety monitoring systems and infrastructure, assessing current practices and providing recommendations to strengthen national vaccine risk surveillance.

View Report →
Congressional Briefings
October 2025
Prepared an invited briefing on Vaccine Risk Monitoring and Evaluation at the Centers for Disease Control and Prevention for Congressional staff of the U.S. House and Senate Appropriations Committees and the Senate HELP Committee.
May 2024
Prepared an invited briefing on COVID-19 vaccine safety for Congressional staff of the U.S. House and Senate Appropriations Committees and the Senate HELP Committee.
VA
DoD

Neurodegenerative Outcomes and Selected Military Exposures

A National Academies consensus study — sponsored by the Department of Veterans Affairs — conducting a systematic review of evidence linking six categories of military-service exposures (pesticides, jet fuels, solvents, heavy metals, PFAS, and particulate matter) to neurodegenerative conditions including Parkinson's disease, Alzheimer's disease, dementia, and peripheral neuropathy in Gulf War and Post-9/11 veterans.

View Project →
DoD

Direct Neurocognitive Effects of SARS-CoV-2 Infection Across the Lifespan and Implications for U.S. Military and Veteran Health

A National Academies consensus study — sponsored by the Department of Defense — examining the state of scientific evidence on how SARS-CoV-2 infection affects neurocognitive function across all age groups, with a focus on learning and academic performance, occupational impacts, and implications for military force readiness and veteran health.

View Project →
Education
Teaching

Teaching has been part of my life since long before I was formally a teacher. It started at the Franklin Institute in Philadelphia, where I began as a high school volunteer and eventually developed educational programming and curriculum for public audiences and summer camps. That experience taught me something I still carry into every classroom: if a concept isn't landing, you find another way in.

I teach science as a process of discovery rather than a collection of facts to memorize. In my classroom, I want students to understand not only what is happening, but why — and how they can work through it themselves. I rely on guided discussion, Socratic questioning, collaborative activities, and real-world case studies. For example, rather than simply telling students that antibiotics don't work on viruses, I ask them to explore how antibiotics work, what they target, and what features different organisms have, so they arrive at that connection themselves.

My teaching has spanned a wide range of learners — community college students returning to school after years away, undergraduates entering health professions, graduate and medical students, postdoctoral fellows, and neonatology fellows. At Rowan College at Burlington County, I created the Health and Human Microbiology course for health-profession students and have taught Biology I, Biology II, and Basic Microbiology. At Drexel University College of Medicine and Uniformed Services University, I lecture in microbiology, immunology, molecular pathogenesis, and vaccine development.

Good teaching, to me, is not about simplifying material until it loses its depth. It's about presenting it with clarity, structure, and relevance — and making sure students feel supported enough to engage actively with challenging ideas. My goal is for students to leave not just knowing more biology, but better equipped to question, analyze, and think for themselves.

Teaching & Mentorship

Microbiology, Immunology, Vaccine Development
Drexel University College of Medicine & Uniformed Services University
Health & Human Microbiology / Biology I & II
Rowan College at Burlington County — Course Creator
Instructor, Curriculum Designer
Philadelphia University
Science Educator & Program Developer
The Franklin Institute, Philadelphia
Teaching Assistant
University of the Sciences in Philadelphia
Graduate Student Association President
Drexel University College of Medicine (2 years)
Publications
PubMed Profile ORCID Profile
Rao AS, Onufer AP, Kumova OK, Roberts LTN, Mossabeb R, Pascasio J, Carey AJ.
Myeloid TLR2 signaling amplifies immunopathology in influenza-infected murine neonates.
American Journal of Respiratory Cell and Molecular Biology. In press.
Matthias KA, Connolly KL, Jerse AE, Kumova OK, et al.
Evaluation of immunization route in induction of vaccine-mediated anti-gonococcal immune responses in a murine model of ascending infection.
Journal of Infectious Diseases. 2025;232(5):e765–e777.
Rao AS, Ugwu N, Onufer AP, Kumova OK, Carey AJ.
Cathelicidin-related antimicrobial peptide (CRAMP) is toxic during neonatal murine influenza virus infection.
Journal of Immunology. 2025;214(5):1022–1031.
Kumova OK, Galani IE, Rao A, Johnson H, Triantafyllia V, Matt SM, Pascasio J, Gaskill PJ, Andreakos E, Katsikis PD, Carey AJ.
Severity of neonatal influenza infection is driven by type I interferon and oxidative stress.
Mucosal Immunology. 2022;15(6):1309–1320.
Marin C, Kumova OK, Ninio S.
Characterization of a novel regulator of biofilm formation in the pathogen Legionella pneumophila.
Biomolecules. 2022;12(2):225.
Das P, Acharya S, Prahaladan VM, Kumova OK, et al.
Chitin-derived AVR-48 prevents experimental bronchopulmonary dysplasia and BPD-associated pulmonary hypertension in newborn mice.
International Journal of Molecular Sciences. 2021;22(16):8547.
Chaubey S, Nader YM, Shah D, Kumova OK, et al.
α1,3-Fucosyltransferase-IX, an enzyme of pulmonary endogenous lung stem cell marker SSEA-1, alleviates experimental bronchopulmonary dysplasia.
Pediatric Research. 2021;89(5):1126–1135.
Gary E, O'Connor M, Chakhtoura M, Tardif V, Kumova OK, et al.
Adenosine deaminase-1 enhances germinal center formation and functional antibody responses to HIV-1 envelope DNA and protein vaccines.
Vaccine. 2020;38(22):3821–3831.
Kumova OK, Fike AJ, Thayer JL, Nguyen LT, Mell JC, Pascasio J, Stairiker C, Leon LG, Katsikis PD, Carey AJ.
Lung transcriptional unresponsiveness and loss of early influenza virus control in infected neonates is prevented by intranasal Lactobacillus rhamnosus GG.
PLoS Pathogens. 2019;15(10):e1008072.
Fike AJ, Kumova OK, Carey AJ.
Dissecting the defects in the neonatal CD8+ T-cell response.
Journal of Leukocyte Biology. 2019;106(5):1051–1061.
Fike AJ, Kumova OK, Tardif VJ, Carey AJ.
Neonatal influenza-specific effector CTLs retain elevated CD31 levels at the site of infection and have decreased IFN-γ production.
Journal of Leukocyte Biology. 2019;105(3):539–549.
Carey AJ, Hope JL, Mueller YM, Fike AJ, Kumova OK, et al.
Public clonotypes and convergent recombination characterize the naïve CD8+ T-cell receptor repertoire of extremely preterm neonates.
Frontiers in Immunology. 2017;8:1859.
Fike AJ, Nguyen LT, Kumova OK, Carey AJ.
Characterization of CD31 expression on murine and human neonatal T lymphocytes during development and activation.
Pediatric Research. 2017;82(1):133–140.
Goodwin IP, Kumova OK, Ninio S.
A conserved OmpA-like protein in Legionella pneumophila required for efficient intracellular replication.
FEMS Microbiology Letters. 2016.
Fike AJ, Kumova OK, Carey AJ.
Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice.
Journal of Immunology.
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Curriculum Vitae

Download my full CV or a targeted resume for specific positions in research, science policy, or teaching.

Full CV (PDF) Research Resume Teaching CV
Contact

I'm always happy to connect with colleagues, collaborators, and anyone interested in vaccine science, immunology, or science policy. I welcome conversations about collaboration, shared interests, and new directions.

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